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PUBLICATIONS

 International Scientific Articles

Year 2023

80. Chen, Y., Sampat, C., Huang, Y., Ganesh, S., Singh, R., Ramachandrana. R., Reklaitis, G. V., Ierapetritou, M. (2023). An integrated data management and informatics framework for continuous drug product manufacturing processes: A case study on two pilot plants. International Journal of Pharmaceutics, 642. https://doi.org/10.1016/j.ijpharm.2023.123086.

79. Singh, R. (2023). Pharma 4.0: Advanced continuous pharmaceutical tablet manufacturing. Pharma Focus America. Accepted.

78. Singh, R. (2023). Advanced continuous manufacturing of drug. Pharmaceutical Technology. Trends in Manufacturing eBook, 20-26, May 2023. https://www.e-digitaleditions.com/i/1499609-pharmaceutical-technology-may-2023/19?

77. Chen, Y., Kotamarthy, L., Dana, A., Sampat, C., Bhalode, P., Singh, R., Glasser, B. J., Ramachandrana. R. Ierapetritou, M., (2023). Optimization of key energy and performance metrics for drug product manufacturing. International Journal of Pharmaceutics. 631:122487, PMID: 36521636. DOI: https://doi.org/10.1016/j.ijpharm.2022.122487.

76. Singh, R. (2023). Advanced model predictive control system of continuous biopharmaceutical manufacturing process. Pharma Focus America, 64-71, Issue 1, 2023.

Years 2022-2021

75. Sampat, C., Kotamarthy, L., Bhalode, P., Chen, Y., Dana, A., Parvani, S., Dholakia, Z., Singh, R., Glasser, B. J., Ierapetritou, M., Ramachandrana. R. (2022). Enabling Energy-Efficient Manufacturing of Pharmaceutical Solid Oral Dosage Forms via Integrated Techno-Economic Analysis and Advanced Process Modeling. Journal of Advanced Manufacturing and Processing – AICHE. https://doi.org/10.1002/amp2.10136.

74. Bhalode, P., Tian H., Gupta, S., Razavi, S., Roman-Ospino, A., Talebian, S., Singh, R., Scicolone, J., Muzzio, F.J., Ierapetritou, M. (2021). Using residence time distribution in pharmaceutical solid dose manufacturing – A critical review. International Journal of Pharmaceutics, 610, 121248. https://doi.org/10.1016/j.ijpharm.2021.121248.

73. Sánchez-Paternina, A., Martínez-Cartagena, P., Li, J., Scicolone, J., Lugo, Y.C., Romañach, R. J., Muzzio, F.J., Román-Ospino, A. D. . Residence time distribution as a traceability method for lot changes in a pharmaceutical continuous manufacturing system. International Journal of Pharmaceutics. 611, 121313. https://doi.org/10.1016/j.ijpharm.2021.121313.

72. Román-Ospino, A. D., Baranwal, Y., Li, J., Vargas, J., Igne, B., Bate, S., Brouckaert, D., Chauchard, F., Hausner, D., Ramachandran, R., Singh, R., Muzzio, F. J. (2021). Sampling optimization for blend monitoring of a Low Dose formulation in a Tablet Press Feed Frame Using Spatially Resolved Near-Infrared Spectroscopy. Analytical Chemistry. International Journal of Pharmaceutics, 602, 120594. https://doi.org/10.1016/j.ijpharm.2021.120594.

71. Chopda, V., Gyorgypal, A, Yang O., Singh, R., Ramachandran, R., Zhang, H., Tsilomelekis, G., Chundawat, S., Ierapetritou, M. (2021). Recent Advances in Integrated Process Analytical Techniques, Modeling, and Control Strategies to Enable Continuous Biomanufacturing of Monoclonal Antibodies. Journal of Chemical Technology and Biotechnology. https://doi.org/10.1002/jctb.6765.

70. Furukawa, R., Singh, R., Ierapetritou, M. (2021). Experimental investigation and modelling of tensile strength of pharmaceutical tablets based on shear force applied by feed frame paddles. International Journal of Pharmaceutics. 606, 120908. https://doi.org/10.1002/jctb.6765.

69. Singh, R. (2021). Cyber-Physical Security (CPS) Tool for Continuous Pharmaceutical Manufacturing Process. Pharma Focus Asia. Issue 44, 41-49.

68. Singh, R. . Predicting tablet potency in continuous manufacturing. A modular toolbox enables residence time distribution-based control for continuous pharmaceutical manufacturing. Pharmaceutical Technology. 44-48. https://www.e-digitaleditions.com/i/1420709-pharmaceutical-technology-oct-2021-api/44?

67. Tanimura, S., Singh, R., Román-Ospino, A. D., Ierapetritou, M. (2021). Residence time distribution modelling and in line monitoring of drug concentration in a tablet press feed frame containing dead zones. International Journal of Pharmaceutics. , 592, 120048. 10.1016/j.ijpharm.2020.120048.

Year 2020

66. Furukawa, R.,Ierapetritou, M. (2020). Effect of material properties on the residence time distribution (RTD) of a tablet press feed frame. International Journal of Pharmaceutics, 591, 119961. https://doi.org/10.1016/j.ijpharm.2020.119961.

65. Román-Ospino, A. D., Tamrakar, A., Igne, B., Dimaso, E. T., Airiau, C., Clancy, D. J., Pereira, G., Muzzio, F. J., Singh, R., Ramachnadran, R. (2020). Characterization of NIR interfaces for the feeding and in-line monitoring of a continuous granulation process. International Journal of Pharmaceutics, 574, 118848. doi: https:// doi.org/10.1016/j.ijpharm.2019.118848.

64. Singh, R. (2020). The cyber-physical security of pharmaceutical manufacturing processes. Pharma., Issue 38, 53-57.

Year 2019

63. Metta, N., Ghijs, M., Schafer, E., Kumar, A., Cappuyns, P., Assche, I. V., Singh, R., Ramachandran, R. De Beer, T., Ierapetritou, M., Nopens, I. (2019). Dynamic flowsheet model development and sensitivity analysis of a continuous pharmaceutical tablet manufacturing process using the wet granulation route. Processes Journal, 7(4), 234.

62.  Singh, R.* (2019). Systematic framework for implementation of RTD based control system into continuous pharmaceutical manufacturing pilot-plant. Pharma, Issue 34, 43-46.

Year 2018

61.   Billups, M., Singh, R.* (2018). Systematic framework for implementation of material traceability into continuous pharmaceutical tablet manufacturing process. Journal of Pharmaceutical Innovation. https://doi.org/10.1007/s12247-018-9362-9.

60.   Bhaskar, A., Singh, R.* (2018). Residence time distribution (RTD) based control system for continuous pharmaceutical manufacturing process. Journal of Pharmaceutical Innovation. DOI: 10.1007/s12247-018-9356-7.

59.   Pereira, G., Muddu, S. V., Román, A., Clancy, D., Igne, B., Airiau, C., Muzzio, F. J., Ierapetritou, M., Ramachnadran, R., Singh, R.* (2018). Combined Feed-forward/Feed-back Control of an Integrated Continuous Granulation Process. Journal of Pharmaceutical Innovation. Accepted. DOI: 10.1007/s12247-018-9347-8.

58.   Shaikh, R., Singh, R., Walker, G. M., Croker, D. M. (2018). Pharmaceutical Cocrystals: An outlook on product development. Trends in pharmaceutical sciences. https://doi.org/10.1016/j.tips.2018.10.006.

57.   Metta, N., Verstraeten, M., Ghijs, M., Kumar, A., Schafer, E., Singh, R., De Beer, T., Nopens, I., Ierapetritou, M., Ramachandran, R. (2018). Model development and prediction of particle size distribution, density and friability of a comilling operation in a continuous pharmaceutical manufacturing process. International Journal of Pharmaceutics, 549 (1-2), 271-282.

56.   Cao, H., Mushnoori, S., Higgins, B., Kollipara, C., Fermier, A., Hausner, D., Jha, S., Singh, R., Ierapetritou, M., and Ramachandran, R. (2018). Systematic Framework for Data Management and Integration in a Continuous Pharmaceutical Manufacturing Processing Line. Processes Journal. 6(5), 53. https://doi.org/10.3390/pr6050053.

55.   Escotet-Espinoza, M. S., Vadodaria, S., Singh, R., Muzzio, F. J., Ierapetritou, M. G. (2018). Modeling the effects of material properties on tablet compaction: A building block for controlling both batch and continuous pharmaceutical manufacturing processes. International Journal of Pharmaceutics, 543 (1-2), 274-287.

54.   Moghtadernejad, S., Escotet-Espinoza, M. S., Oka, S., Singh, R., et al. (2018).  A Training on: Continuous Manufacturing (Direct Compaction) of Solid Dose Pharmaceutical Products. Journal of Pharmaceutical Innovation, 13(2), 155-187. https://doi.org/10.1007/s12247-018-9313-5.

53.   Billups, M., Singh, R.* (2018). Material Traceability in Continuous Pharmaceutical Tablet Manufacturing. Pharmaceutical Technology 42 (2), 32-35, 59.

52.   Singh, R.* (2018). Residence Time Distribution (RTD) model: Novel applications to continuous pharmaceutical manufacturing. Pharma. Issue 32, 39-42.

51.   Singh, R.* (2018). Drug concentration assurance of continuous tablet manufacturing: Advanced process control strategy.  Pharma. Issue 31, 34-38.

50.   Singh, R.* (2018). System engineering for a novel continuous pharmaceutical manufacturing process. Pharma. Issue 30. https://www.pharmafocusasia.com/manufacturing/system-engineering-pharmaceutical-manufacturing-process.

Year 2017

49.   Barros, F. N., Bhaskar, A., Singh, R.* (2017). A validated model for design and evaluation of control architectures for continuous tablet compaction process. Processes Journal, 5(4), 76. doi:10.3390/pr5040076

48.   Bhaskar, A., Barros, F. N., Singh, R.* (2017). Development and implementation of an advanced model predictive control system into continuous pharmaceutical tablet compaction process. International Journal of Pharmaceutics, 534 (1-2), 159-178. https://doi.org/10.1016/j.ijpharm.2017.10.003.

47.   Haas, N. T., Ierapetritou, M., Singh, R.* (2017). Advanced model predictive feedforward/feedback control of a tablet press. Journal of Pharmaceutical Innovation, 12 (2), 10-123. DOI 10.1007/s12247-017-9276-y.

46.   Singh, R.* (2017). A novel continuous pharmaceutical manufacturing pilot-plant: Advanced model predictive control. Pharma, Issue 28, PP 58-62. https://www.pharmafocusasia.com/manufacturing/novel-continuous-pharmaceutical-manufacturing.

45.   Wang, Z., Escotet-Espinoza, M. S., Singh, R., Ierapetritou, M. G. (2017). Surrogate-Based Optimization for Pharmaceutical Manufacturing Processes. Computer Aided Chemical Engineering, 40, 2797-2802. https://doi.org/10.1016/B978-0-444-63965-3.50468-2

 

Year 2016

44. Román-Ospino, A. D., Singh, R., Ierapetritou, M., Ramachandran, R. Méndez, R., Ortega, C., Muzzio, F. J., Romañach, R. J., (2016). Near Infrared Spectroscopic Calibration Models For Real Time Monitoring Of Powder Density. International Journal of Pharmaceutics,512 (1), 61-74. http://dx.doi.org/doi:10.1016/j.ijpharm.2016.08.029.

43. Wu, S., Panikar, S. S., Singh; R., Zhang, J., Donepudi, A., Glasser, B., Ramachandran, R. (2016). Systematic framework to monitor mulling processes using Near Infrared spectroscopy. Advanced Powder Technology, 27 (4), 1115-1127. doi:10.1016/j.apt.2016.03.022.

42. Singh, R., Muzzio, F., Ierapetritou, M., Ramachandran, R. (2016). Systematic framework for design and implementation of plant-wide multilayer, sensing and control architecture into continuous pharmaceutical manufacturing plant. Computer Aided Chemical Engineering. Computer Aided Chemical Engineering, 38, 1473-1478.

 

Year 2015

41. Singh, R., Román-Ospino, A. D., Romañach, R. J., Ierapetritou, M., Ramachandran, R. (2015). Real time monitoring of powder blend bulk density for coupled feed-forward/feed-back control of a continuous direct compaction tablet manufacturing process. International Journal of Pharmaceutics, 495, 612-625. Citation >1.

40. Singh, R., Muzzio, F., Ierapetritou, M., Ramachandran, R. (2015). A combined feed-forward/feed-back control system for a QbD based continuous tablet manufacturing process. PROCESSES Journal, 3, 339-356. Citations > 2.

39. Singh, R., Sen, M., Ierapetritou, M., Ramachandran, R. (2015). Integrated moving horizon based dynamic real time optimization and hybrid MPC-PID control of a direct compaction continuous tablet manufacturing process. Journal of Pharmaceutical Innovation, 10 (3), 233-253. Citations>1.

38. Simon, L. L., .. Singh, R., et al. (2015). Assessment of Recent Process Analytical Technology (PAT) Trends: A Multi-author Review. Organic Process Research & Development, 19, 3-62. Citations>28.

37. Singh, R., Zhang, J., Ierapetritou, M., Ramachandran, R. (2015). Designing a novel continuous manufacturing plant with superior monitoring and control. European Pharmaceutical Review, 20(6), 37-41.

36. Sen, M., Singh, R., Ramachandran, R. (2015). Model Manufacturing. The Medicine Maker, February, 05, 42-45.

35. Escotet-Espinoza, M. S., Singh, R., Sen, M., O’Connor, T., Lee, S., Chatterjee, S., Ramachandran, R., Ierapetritou, M., Muzzio, F. (2015). Flowsheet Models Modernize Pharmaceutical Manufacturing Design and Risk Assessment, Pharmaceutical Technology 39 (4), 34-42. Citations>2.

34. Singh, R., Muzzio, F., Ierapetritou, M., Ramachandran, R. (2015). Plant-wide control of a continuous tablet manufacturing for Quality-by-Design based pharmaceutical manufacturing. Computer Aided Chemical Engineering, 37, 2183 - 2188.

33. Karry, K. M., Singh, R., Muzzio, F. J. (2015). Fit-for-Purpose Miniature NIR Spectroscopy for Solid Dosage Continuous Manufacturing. American Pharmaceutical Review, 18(4), 64 - 67.

32. Singh, R., Ierapetritou, M., Ramachandran, R. (2015). The scopes of PAT in real-time advanced control of tablet quality. European Pharmaceutical Review 20(2), 76-80. Citations>2.

Year 2014

31. Singh, R., Sahay, A., Karry, K. M., Muzzio, F., Ierapetritou, M., Ramachandran, R. (2014). Implementation of a hybrid MPC-PID control strategy using PAT tools into a direct compaction continuous pharmaceutical tablet manufacturing pilot-plant. International Journal of Pharmaceutics, 473, 38–54. Citations>16.

30. Singh, R., Sahay, A., Fernando Muzzio, Ierapetritou, M., Ramachandran, R. (2014). Systematic framework for onsite design and implementation of the control system in continuous tablet manufacturing process. Computers & Chemical Engineering Journal, 66, 186-200. Citations>19.

29. Singh, R., Barrasso, D., Chaudhury, A., Maitraye Sen, Ierapetritou, M., Ramachandran, R. (2014). Closed-Loop Feedback Control of a Continuous Pharmaceutical Tablet Manufacturing Process via Wet Granulation. Journal of Pharmaceutical Innovation, 9, 16-37.  Citations>11

28. Sen, M., Barrasso, D., Singh, R., Ramachandran, R. (2014). A Multi-Scale Hybrid CFD-DEM-PBM Description of a Fluid-Bed Granulation Process. Processes Journal, 2(1), 89-111. Citations>11.

27. Sen, M., Singh, R., Ramachandran, R. (2014). Simulation based design of an efficient control system for the continuous purification and processing of active pharmaceutical ingredients. Journal of Pharmaceutical Innovation, 9, 65-81. Citations>7.

26. Sen, M., Singh, R., Ramachandran, R. (2014). A hybrid MPC-PID control system design for the continuous purification and processing of active pharmaceutical ingredients. PROCESSES Journal, 2, 392-418; doi:10.3390/pr2020392. Citations>2.

25. Sen, M., Chaudhury, A., Singh, R., Ramachandran, R. (2014). Two-dimensional population balance model development and validation of pharmaceutical crystallization processes. American Journal of Modern Chemical Engineering, 1, 13-29. Citations>2.

Year 2013

24. Singh, R., Ierapetritou, M., Ramachandran, R. (2013). System-wide hybrid model predictive control of a continuous pharmaceutical tablet manufacturing process via direct compaction. European Journal of Pharmaceutics and Biopharmaceutics, 85(3), Part B, 1164-1182. Citations>34.

23. Singh, R., Godfrey, A., Gregertsen, B., Muller, F., Gernaey, K. V., Gani, R., Woodley, J. M. (2013). Systematic substrate adoption methodology (SAM) for future flexible, generic pharmaceutical production processes. Computers & Chemical Engineering Journal, 58, 344 - 368. Citations>5.

22. Sen, M., Dubey, A., Singh, R., Ramachandran, R. (2013). Mathematical Development and Comparison of a Hybrid PBM-DEM description of a Continuous Powder Mixing Process. Journal of Powder Technology, http://dx.doi.org/10.1155/2013/843784. Citations>19.

21. Sen, M., Chaudhury, A., Singh, R., John, J., Ramachandran, R. (2013). Multi-scale flowsheet simulation of an integrated continuous purification–downstream pharmaceutical manufacturing process. International Journal of Pharmaceutics, 445 (1-2), 29-38. Citations>30.

20. Sen, M., Rogers, A., Singh, R., Chaudhury, A., John, J., Ierapetritou, M., Ramachandran, R. (2013). Flowsheet optimization of an integrated continuous purification-processing pharmaceutical manufacturing operation. Chemical Engineering Science, 102, 56 – 66. Citations>20.

19. Singh, R., Ierapetritou, M., Ramachandran, R (2013). Hybrid advanced control of a flexible multipurpose continuous pharmaceutical tablet manufacturing process via direct compaction. Computer Aided Chemical Engineering, 32, 757-762. Citations>4.

18. Muzzio, F., Singh, R., Chaudhury, A., Rogers, A., Ramachandran, R. Ierapetritou, M. (2013). Model- predictive design, control and optimization of pharmaceutical process. Pharmaceutical Technology magazine, 37(6), 40-41, 77. Citations>5.

17. Singh, R., Sahay, A., Oka, S., Liu, X., Ramachandran, R., Ierapetritou, M., Muzzio, F. (2013). Online monitoring, advanced control and operation of robust continuous pharmaceutical tablet manufacturing process. BioPharma magazine Asia, 2(5), 18-25.  Citations>3.

Year 2012

16. Singh, R., Ierapetritou, M., Ramachandran, R. (2012). An engineering study on the enhanced control and operation of continuous manufacturing of pharmaceutical tablets via roller compaction. International Journal of Pharmaceutics, 438 (1-2), 307-326. Citations>38.

15. Sen, M., Singh, R., Vanarase, A., John, J., Ramachandran, R. (2012). Multi-dimensional population balance modeling and experimental validation of continuous powder mixing processes. Chemical Engineering Science, 18, 349-360. Citations>33.

14. Singh, R., Raquel Rozada-Sanchez, R., Dean, W., Perkins, J., Muller, F., Godfrey, A., Gernaey, K. V., Gani, R., Woodley, J. M. (2012). A generic process template for continuous pharmaceutical production. Computer Aided Chemical Engineering, 31, 715-719. Citations>3.

13. Singh, R., Boukouvala, F., Jayjock, E., Ramachandran, R. Ierapetritou, M., Muzzio, F. (2012). Flexible Multipurpose Continuous Processing. PharmPro Magazine, Pharmaceutical Processing, 27(6), 22-25. Citations>11.

12. Singh, R., Boukouvala, F., Jayjock, E., Ramachandran, R. Ierapetritou, M., Muzzio, F. (2012). Flexible Multipurpose Continuous Processing of Pharmaceutical Tablet Manufacturing Process. GMP news, European Compliance Academic (ECE), http://www.gmp-compliance.org/ecanl_503_0_news_3268_7248_n.html. Citations>10.

Years 2011-2008

11. Singh, R., Gernaey, K. V., Gani, R. (2010). ICAS-PAT: A Software for Design, Analysis & Validation of PAT Systems. Computers & Chemical Engineering Journal, 34(7), 1108-1136. Citations>36.

10. Singh, R., Gernaey, K. V., Gani, R. (2010). An ontological knowledge based system for selection of process monitoring and analysis tools. Computers & Chemical Engineering Journal, 34(7), 1137-1154. Citations>30.

09. Singh, R., Gernaey, K. V., Gani, R. (2009). Model-based computer-aided framework for design of process monitoring and analysis systems. Computers & Chemical Engineering Journal, 33(1), 22-42. Citations>54.

08. Samad, N. A. F. A., Singh, R., Sin, G., Gernaey, K. V., Gani, R. (2011). A generic multi-dimensional model-based system for batch cooling crystallization processes. Computers & Chemical Engineering Journal, 35(5), 828-843. Citations>25.

07. Samad, N. A. F. A., Singh, R., Sin, G., Gernaey, K. V., Gani, R. (2011). Systematic Procedure for Generating Operational Policies to Achieve Target Crystal Size Distribution (CSD) in Batch Cooling Crystallization. IEEE, 1-6. Print ISBN: 978-1-4577-0003-3. DOI: 10.1109/ICMSAO.2011.5775588.     

06. Gani, R., Singh, R., PAT Slowly Yielding to Broader QbD (2011). GEN: Genetic Engineering & Biotechnology News, 31(6), 40-41. Citations>4.

05. Samad, N. A. F. A., Singh, R., Sin, G., Gernaey, K. V., Gani, R. (2011). Integration of Generic Multi-dimensional Model and Operational Policies for Batch Cooling Crystallization. Computer Aided Chemical Engineering, 29, 86-90. Citations>3.

04. Samad, N. A. F. A., Singh, R., Sin, G., Gernaey, K. V., Gani, R. (2010). Control of process operation and monitoring of product qualities through generic model-based in batch cooling crystallization. Computer Aided Chemical Engineering, 28, 613-618. Citations>4.

03. Singh, R., Rozada-Sanchez, R., Wrate, T., Muller, F., Gernaey, K. V., Gani, R., Woodley, J. M. (2010). A retrofit strategy to achieve “Fast, Flexible, Future (F3)” pharmaceutical production processes. Computer Aided Chemical Engineering, 29, 291-295. Citations>11.

02. Singh, R., Gernaey, K. V., Gani, R. (2009). A software tool for design of process monitoring and analysis systems. Computer Aided Chemical Engineering, 26, 321-326. Citations>1.

01. Singh, R., Gernaey, K. V., Gani, R. (2008). Off-line design of PAT systems for on-line applications. Computer Aided Chemical Engineering, 25, 423-428. Citations>2.

 

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