Pharmaceutical Systems Engineering

Research Projects (Principal/Co-Principal Investigator: PI/Co-PI)

(20). 2022 -2025: Food & Drug Administration (FDA) (granted)

A model-based systems engineering approach to end-to-end pharmaceutical manufacturing of liquid dosage forms.

Role: Rutgers PI (and project technical lead). Source: FDA. Amount: $5 Million.

(19). 2021 -2023: Thermo Fisher Scientific (granted)

Configuring the Continua Digital Twin to include a continuous wet granulation module.

Role: Co-PI (and project technical lead). Source: Thermo Fisher Scientific. Amount: $120000.

(18). 2021 -2023: Food & Drug Administration (FDA) (granted)

Integrated toolbox for digital design, scale-up, control, and optimization of advanced API
manufacturing processes.

Role: Co-PI (and project technical lead). Source: FDA. Amount: $4.198914 Million.

(17). 2020-2021: DARPA (granted)

ProSyn-Agile Manufacturing of APIs for Rapid Response to Emerging Biological Threats and Pandemics.

Flow-sheet model-based optimization, scale-up, and process control of a continuous flow reactor system

Role: Co-PI and project lead.  Source: DARPA. Amount: $800,000.

(16). 2020-2022: CESMII (granted)

Using Smart Manufacturing to enable energy-efficient manufacturing of pharmaceutical products. 

Role: Co-PI.  Source: CESMII. Amount: $1,134,022.

(15). 2020-2022: Research Council Award (granted)

Systematic framework for cyber-physical security of continuous pharmaceutical and biopharmaceutical manufacturing processes. Role: PI. Source: Rutgers. Amount: $3500.

(14). 2019-2020: Glaxo Smith Kline (GSK) (granted)

Development of Computational Models for Continuous Tablet Manufacturing

Role: PI. Source: GSK Company. Amount: $540,000.

(13). 2019-2020: Siemens (granted)

Enable full implementation of “Integrated Cyber-Physical Security Framework and Novel Control Module” for continuous pharmaceutical manufacturing plant

Role: PI. Source: Siemens Company. Amount: $71,800.

(12). 2019-2020: Haldor Topsoe (granted)

Robustness of the continuous pharmaceutical manufacturing process model when applied to Haldor-Topsoe’s materials

Role: Co-PI. Amount: $26,850.

(11). 2018-2021: Food & Drug Administration (FDA) (granted)

Advanced Bio-manufacturing

Role: Co-PI.  Source: FDA. Amount: $1,800,000 (1.8 Million)

(10). 2018 -2021: Food & Drug Administration (FDA) (granted)

Industry 4.0 Implementation in Continuous Pharmaceutical Manufacturing

Role: Co-PI.  Source: FDA. Amount: $3,956,527 (3.96 Million)

(9). 2018-2019: Glaxo Smith Kline (GSK) (granted)

Development of Computational Models for Continuous Tablet Manufacturing

Role: PI. Source: GSK Company. Amount: $539,991.

(8). 2018-2019: Siemens (granted)

Cyber-physical attack in the Pharmaceutical Manufacturing Process

Role: PI. Source: Siemens Company. Amount: $78,750.

(7). 2018-2019: CNH (granted)

Wear prediction and validation with fine particle interaction

Role: Co-PI. Source: CNH Company. Amount: $118608.

(6). 2018: Diversitech Corporation (granted)

Fluid bed drying trials

Role: PI. Source: Diversitech Company. Amount: $1600.

(5). 2018 Rutgers Global International Travel Grant (granted)

Role: PI. Amount: $750.

(4). 2017-2018: Glaxo Smith Kline (GSK) (granted)

Development of tablet press feed frame RTD model and BU to CU relation

Role: Co-PI. Source: GSK Company. Amount: $150000.

(3). 2017: Grant to stablish international collaboration (granted)

Grants to Support the Initiation of International Collaboration.

Role: Co-PI. Source: Hamburg University of Technology. Amount: €1610.

(2). 2016: Integra Continuous Manufacturing Systems (granted)

Development of sensing and control strategy for direct compaction continuous pharmaceutical tablet manufacturing process. Role: PI. Source: Acumen Company. Amount: $5114.

(1). 2016: Research Council Grant Award (granted)

Development and validation of advanced model predictive feedforward/feedback control strategy for pharmaceutical process. Role: PI. Source: Rutgers. Amount: $3800.

 

Completed Research Projects

1. 2015 GSK (granted)

Integration of PAT and process models into a continuous manufacturing line

Role: Project manager and key researcher. Amount: $200,000

2. 2014 Johnson & Johnson (granted)

Modeling, PAT and control development for ConsiGma/Tramacet

Role: Project manager and key researcher. Source: JnJ Company. Amount: $1,000,000

3. 2014 Johnson & Johnson

J&J expansion of continuous pharmaceutical manufacturing

Role: Project manager and key researcher. Amount: $3,500,000

4. 2014 Food & Drug Administration (FDA)

Flowsheet modeling and analysis tools for solid base pharmaceutical products manufacturing

Role: Project manager and key researcher. Award: $500,000

5. 2014 Process Systems Enterprise

Flowsheet modeling and database development of tabet manufacturing processes

Role: Project manager. Award: $70,000

6. 2014 Johnson & Johnson

Flowsheet modeling of Inspire tablet manufacturing line

Role: Project manager and key researcher. Amount: $131,273

7. 2014 Johnson & Johnson

Rutgers support for Continuation of Continuous Process Development Phase II

Role: Project manager and key researcher. Amount: $488,683